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已认为病毒是造成心瓣膜病的一个原因,用柯萨奇B病毒作实验可引起小鼠和短尾猴的心内膜炎。在人类,这些病毒常引起新生儿严重的和致命性的心肌炎和成人的心包炎。也曾有人诊断和怀疑过由于柯萨奇B病毒引起的急性瓣膜炎,已证明有该病毒的抗原在“慢性风湿性心脏”患者心瓣膜中,但很少注意到去研究这些病人的病毒中和抗体。作者对29例临床上诊断为“风湿性病原学”的获得性心瓣膜病患者对6种血清型的柯萨奇B组病毒特异中和抗体滴定值作了测定。29例患者均有二尖瓣狭窄,伴有二尖瓣反流者7例;主动脉瓣反流者12例;主动脉瓣狭窄者4例。均在手术前收集血清,每例均有2例年龄相配者作对照。患者抗体几何学的平均滴定值。(附表)
One of the causes of heart valve disease has been considered as a cause of heart valve disease and endocarditis can be induced in mice and cynomolgus monkeys by experiments with Coxsackie B virus. In humans, these viruses often cause neonatal severe and fatal myocarditis and adult pericarditis. There have also been people who have diagnosed and suspected acute valve inflammation due to Coxsackie B virus and have demonstrated that the antigen of the virus is in the heart valve of patients with “chronic rheumatic heart”, but little attention has been paid to the study of the virus in these patients And antibodies. The author of 29 patients clinically diagnosed as “rheumatic etiology” of acquired valvular disease in patients with six serotypes Coxsackie B virus-specific neutralizing antibody titer was determined. All 29 patients had mitral stenosis, with mitral regurgitation in 7 cases, aortic regurgitation in 12 cases and aortic valve stenosis in 4 cases. Serum were collected before surgery, each case has 2 age-matched control. The average titration of patient antibody geometry. (Schedule)