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One new 6,7-seco-enr-kaurane diterpenoid,sculponin T(1),was isolated from the aerial parts of Isodon sculponeatus,along with four known analogs,sculponeatin J(2),sculponeatin K(3),sculponeatin C(4),and sculponeatin Q(5).Their structures were elucidated by extensive spectroscopic analysis and by comparison with data reported in the literature.Significant cytotoxic activity was observed for compound 2 against five human tumor cell lines with IC_(50) values ranging from 1.8 μmol/L to 3.3 μmol/L,and it also inhibited NO production in LPS-stimulated RAW264.7 cells,with IC_(50) value of 3.3 μmol/L.
One new 6,7-seco-enr-kaurane diterpenoid, sculponin T (1), was isolated from the aerial parts of Isodon sculponeatus, along with four known analogs, sculponeatin J (2), sculponeatin K (3), sculponeatin C 4), and sculponeatin Q (5) .Their structures were elucidated by extensive spectroscopic analysis and by comparison with data reported in the literature. Identification of cytotoxic activity was observed for compound 2 against five human tumor cell lines with IC_ (50) values ranging from 1.8 μmol / L to 3.3 μmol / L, and it also inhibited NO production in LPS-stimulated RAW264.7 cells with IC 50 value of 3.3 μmol / L.