Noninvasive blood glucose detection using a miniature wearable Raman spectroscopy system

• 作 者: 郑毅 朱香平 王哲 侯宗余 高飞 聂荣志 崔晓霞 佘江波 彭波
• 机 构: State Key Laboratory of Transient Optics and Photonics, Xi’an Institute of Optics and Precision Mech
• 出 处: Chinese Optics Letters
• 发表日期: 2017年08期
• 关键词: miniature multivariate termination collection calibration feasible convenient op

In this Letter, a miniature wearable Raman spectroscopy system is developed. A wearable fiber-optic probe i employed to help the stable and convenient collection of Raman spectra. A nonlinear partial least squares mode based on a multivariate dominant factor is employed to predict the glucose level. The mean coefficients of de termination are 0.99, 0.893, and 0.844 for the glucose solution, laboratory rats, and human volunteers. Th results demonstrate that a miniature wearable Raman spectroscopy system is feasible to achieve the noninvasiv detection of human blood glucose and has important clinical application value in disease diagnosis.

In this Letter, a miniature wearable Raman spectroscopy system is developed. A wearable fiber-optic probe i employed to help the stable and convenient collection of Raman spectra. A nonlinear partial least squares mode based on a multivariate dominant factor is employed to predict the glucose level. The mean coefficients of de termination are 0.99, 0.893, and 0.844 for the glucose solution, laboratory rats, and human volunteers. Th results demonstrate that a miniature wearable Raman spectroscopy system is feasible to achieve the noninvasiv detection of human blood glucose and has important clinical application value in disease diagnosis.