论文部分内容阅读
目的研发珍珠类脂质体药物新剂型。方法酸解珍珠粉使成珍珠水解液,再用旋转蒸发-冻融法制备珍珠脂质体。电子显微镜观察珍珠脂质体形态并测定粒径分布。结果成功制备了珍珠脂质体;卵磷脂∶胆固醇∶聚乙二醇6000(PEG6000)摩尔比为10∶5∶1时,对珍珠水解液的包封率最大,为31.75%。结论用旋转蒸发-冻融法可以制备珍珠脂质体且较稳定。
Objective To develop a new type of pearl liposomal drug. Methods The pearl hydrolyzate was acid-hydrolyzed into pearl hydrolyzate, and then pearl liposomes were prepared by rotary evaporation-freeze-thawing method. The morphology of pearl liposomes was observed by electron microscopy and the particle size distribution was determined. Results The liposomes were successfully prepared. The highest entrapment efficiency of pearl hydrolyzate was 31.75% when the molar ratio of lecithin: cholesterol: PEG6000 was 10:5:1. Conclusion The pearl liposomes can be prepared by rotary evaporation-freeze-thawing method and are more stable.