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由于注射液的pH、渗透压与体液相差太大或添加剂及杂质而引起的局部反应,通常只要采取相应措施均能使之减轻或消除。本文主要简述克服由药物本身引起的局部刺激性的一些方法。一般的疼痛可添加适合的局部镇痛剂、有机溶媒,如甘油等加以克服;刺激较明显的注射剂可添加碱式氨基酸及其加成盐类、复合无痛化剂或制成前体药物等;能导致局部微循环障碍而引起超刺激的注射剂可添加活血化瘀中药,如丹参溶液等可获满意结果。
Due to the injection of pH, osmotic pressure and body fluids too much difference or additives and impurities caused by local reactions, usually only take appropriate measures can make it reduce or eliminate. This article briefly outlines ways to overcome the local irritation caused by the drug itself. General pain can be added to the appropriate local analgesics, organic solvents, such as glycerol to overcome; more obvious stimuli can be added to the basic amino acids and their addition salts, pain-free compound or made of prodrugs ; Can lead to local microcirculation caused by hyperatimulation injection can add blood circulation Chinese medicine, such as Salvia solution can be satisfactory results.