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笔者应用钙通道阻滞剂心痛定(硝苯吡啶)治疗1例儿童贲门失弛缓症,取得较好的效果,现报告如下.患儿女.9岁,以进食后呕吐3月之主诉入院.入院时患儿呈贫血外貌,消瘦,精神差,X 线钡餐检查见贲门呈线样改变,边缘光滑,贲门上端食管扩张,诊断为贲门失弛缓症.胃镜检查见贲门光滑呈痉挛状态,仅能扩张3～4mm.食管粘膜光滑,血管清晰.入院后经口服颠茄合剂、普鲁本辛均无效,后改为每餐前肌注654—25mg,虽可使症状缓解,但药停病又复发,据此即改为心痛定5mg 和消心痛2.5mg,1日3次共治1周,患儿呕吐停止,观察3周后痊愈出院.出院1月后随访,未见复发.钙通道阻滞硝苯吡啶,由于能阻滞细胞膜的钙离子流入,因而对胃肠道平滑肌的收缩有抑制的作用,还
I applied calcium channel blockers nifedipine (nifedipine) treatment of 1 case of children with achalasia, and achieved good results, are as follows. Children with .9 years old, vomiting after eating the main complaint in March admission. Children admitted to the hospital was anemic appearance, weight loss, poor spirit, X-ray barium meal see the cardia were linear changes, smooth edges, esophageal dilatation of the top of the cardia, diagnosis of achalasia gastroscopy see cardia spasm was smooth, only Expansion of 3 ~ 4mm. Esophageal mucosa smooth, clear blood vessels. After oral administration of belladonna mixture, are not effective, after the change to pre-meal intramuscular injection of 654-25mg, although the symptoms can be alleviated, but the drug stopped sick Relapse, which accordingly changed to nifedipine 5mg and elimination of heartache 2.5mg, co-governance 1 week 3 times on the 1st, children with vomiting stopped, observed 3 weeks after the discharge was cured .After discharge 1 month follow-up, no recurrence .Calcium channel resistance Delayed nifedipine, due to block cell membrane influx of calcium, thus inhibiting the contraction of gastrointestinal smooth muscle, but also