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目的探讨血清CA125在肝硬化患者中的临床意义。方法收集肝硬化患者112例,分为无腹水组37例,腹水组75例;根据Child-Pugh分级对患者肝硬化程度进行分级,A级23例,B级36例,C级19例。另选取健康体检者30例为对照组,检测患者血清CA125水平,并作常规肝功能检查,进行相关性分析。结果随着肝硬化程度的加重,Child分级的增加,患者血清CA125水平逐渐升高,Child C组患者血清CA125水平明显高于Child B组(t=7.216,P<0.05);Child B组显著高于Child A组(t=5.341,P<0.05);肝硬化伴发腹水组患者血清CA125水平明显高于肝硬化无腹水组患者(t=7.241,P<0.05);TBA升高组患者的血清CA125水平显著高于TBA正常组(t=8.314,P<0.05);ALT、DBil升高组与正常组患者血清CA125水平差异无统计学意义。结论肝硬化患者的血清CA125水平与腹水、肝硬化程度明显相关,理论上可以作为临床监测肝硬化患者病情的指标之一。
Objective To investigate the clinical significance of serum CA125 in patients with liver cirrhosis. Methods A total of 112 patients with cirrhosis were enrolled and divided into ascites-free group (n = 37) and ascites-treated group (n = 75). According to Child-Pugh classification, patients were classified as grade A, grade A, grade B, grade 36, and grade C, respectively. Another 30 healthy subjects were selected as the control group, serum CA125 levels were measured, and routine liver function tests were conducted for correlation analysis. Results As the degree of liver cirrhosis aggravated, the level of serum CA125 gradually increased in Child classification, and the level of serum CA125 in Child C group was significantly higher than that in Child B group (t = 7.216, P <0.05); Child B group was significantly higher The level of serum CA125 in patients with cirrhosis and ascites was significantly higher than that in patients without cirrhosis (t = 7.241, P <0.05) in Child A group (t = 5.341, P <0.05) CA125 levels were significantly higher than those in normal TBA group (t = 8.314, P <0.05). There was no significant difference in serum CA125 levels between ALT and DBil group and normal group. Conclusions The level of serum CA125 in patients with cirrhosis is significantly correlated with the degree of ascites and liver cirrhosis and can theoretically be used as one of the indicators of the clinical monitoring of patients with cirrhosis.