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[目的]观察雷莫司琼改善以顺铂为主的化疗方案治疗大肠癌所引起的呕吐症状的临床疗效。[方法]186例大肠癌患者随机分为两组,治疗组用雷莫司琼0.3mg在使用药物化疗前30min静脉推注,对照组用胃复安20mg在使用药物化疗前30min肌注,21d为1个周期,连续观察5d,3周期后评定疗效。[结果]治疗组对呕吐的控制有效率CR+PR为90.57%,远远高于对照组的有效率CR+PR为58.75%,两组差异有统计学意义(P﹤0.05)。[结论]雷莫司琼能更好地改善以顺铂为主的化疗方案,治疗大肠癌所引起的呕吐等上消化道症状。
[Objective] To observe the clinical efficacy of ramosetron in improving chemotherapy of cisplatin-based chemotherapy for vomiting caused by colorectal cancer. [Method] A total of 186 patients with colorectal cancer were randomly divided into two groups. The patients in the treatment group were treated with Ramosetron 0.3mg intravenously 30 minutes before the drug chemotherapy. The control group was given 20mg metoclopramide 30 minutes before the drug chemotherapy and 21 days 1 cycle, continuous observation 5d, 3 cycles after the assessment of efficacy. [Result] The effective rate of CR + PR in the treatment group was 90.57%, much higher than that in the control group (CR + PR, 58.75%). The difference between the two groups was statistically significant (P <0.05). [Conclusion] Ramosetron can better improve the cisplatin-based chemotherapy regimen and treat upper gastrointestinal symptoms such as vomiting caused by colorectal cancer.