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目的抗血小板聚集药物对上消化道出血患者临床病症及影响因素分析。方法采用回顾性分析的研究方法,收集2012年6月~2015年6月入厦门大学附属第一医院治疗消化道出血的110例患者资料,分为2组,对照组79例未服用抗血小板聚集药物治疗,实验组31例服用单一抗血小板聚集药物治疗,观察2组患者的消化道出血程度、出血方式,以及在内镜下表现的特征,参照每位患者的年龄、INR值,服用的药物类型,进一步分析该类药物对上消化道出血患者的临床病症和影响因素。结果实验组消化道出血严重率明显高于对照组(P<0.05),患者年龄越大,消化道出血率越高,在内镜下主要表现为胃炎或溃疡,INR>3的患者消化道出血严重率明显高于INR<3的患者。结论抗血小板聚集药物会明显增加消化道严重出血的机率,患者年龄及药物种类均能影响消化道出血的发生率;长期使用该类药物对十二指肠的影响最为严重,可导致该部位肠粘膜受损;随患者年龄增大,患者消化道的不良反应增大。
Objective To investigate the clinical symptoms and influencing factors of antiplatelet drugs in patients with upper gastrointestinal bleeding. Methods A retrospective analysis method was used to collect the data of 110 patients who were admitted to the First Affiliated Hospital of Xiamen University from June 2012 to June 2015 and divided into two groups and the control group without antiplatelet aggregation Drug treatment, experimental group of 31 patients taking a single anti-platelet aggregation drug treatment to observe the two groups of patients with gastrointestinal bleeding, bleeding patterns, as well as the characteristics of endoscopic performance, with reference to each patient’s age, INR value, taking drugs Type, further analysis of the class of drugs in patients with upper gastrointestinal bleeding clinical symptoms and influencing factors. Results The severity of gastrointestinal bleeding in the experimental group was significantly higher than that in the control group (P <0.05). The older the patients, the higher the rate of gastrointestinal hemorrhage. The main symptoms were gastritis or ulcer under endoscopy, and the patients with INR> 3 had gastrointestinal bleeding The severity was significantly higher in patients with INR <3. Conclusion Anti-platelet aggregation drugs can significantly increase the risk of severe gastrointestinal bleeding, the patient’s age and type of drug can affect the incidence of gastrointestinal bleeding; long-term use of these drugs on the duodenum most affected, can lead to the site of intestine Mucosal damage; with the patient’s age, patients with adverse reactions to the digestive tract increased.