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目的 :探讨基质金属蛋白酶 2 ,9(MMP 2 ,9)与下咽癌组织生物学行为及其与淋巴结转移的相关性。方法 :运用免疫组织化学二步法检测下咽癌组织中MMP 2 ,9抗体的表达。结果 :32例下咽癌组织中MMP 2表达阳性率为 5 3.12 % ,MMP 9为 5 9.38%。MMP 2 ,MMP 9在癌旁正常黏膜中与下咽癌组织中的表达差异均具有统计学意义 (均P <0 .0 1) ;发生淋巴结转移者与未发生转移者的染色差异有统计学意义 (P <0 .0 5 )。结论 :MMP 2 ,9可能与下咽癌的淋巴结转移有关。
Objective: To investigate the biological behaviors of matrix metalloproteinase 2, 9 (MMP 2, 9) and hypopharyngeal carcinoma and their correlation with lymph node metastasis. Methods: Immunohistochemical two-step method was used to detect the expression of MMP 2 and 9 in hypopharyngeal carcinoma. Results: The positive expression rate of MMP 2 in 32 cases of hypopharyngeal carcinoma was 5 3.12% and that of MMP 9 was 5 9.38%. The expressions of MMP 2 and MMP 9 in adjacent normal mucosa and hypopharyngeal carcinoma tissues were significantly different (all P <0.01). There was statistical difference in the expression of MMP 2 and MMP 9 between those with and without lymph node metastasis Significance (P <0. 05). Conclusion: MMP 2, 9 may be related to the lymph node metastasis of hypopharyngeal carcinoma.