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目的:探讨感染丙型肝炎病毒(HCV)的时间、感染的途径、性别、肝功、病毒载量及基因型等因素对疾病的发展至肝硬化的影响。方法:351例慢性丙型肝炎患者分为肝硬化组和非肝硬化两组,对感染HCV致发展为肝硬化的几种因素进行统计学分析。结果:肝硬化组AST水平高于非肝硬化组,ALT水平、HCVRNA水平、性别构成均无差异;基因型1b患者、感染HCV的时间较长的患者、输血感染HCV的患者,更容易发展为肝硬化。结论:感染HCV致发展为肝硬化的受感染时间、感染的途径、AST水平、病毒基因型等因素影响较大,与ALT水平、病毒载量、性别关系不显著。
Objective: To investigate the influence of hepatitis C virus (HCV) infection time, infection route, sex, liver function, viral load and genotype on the development of cirrhosis. Methods: A total of 351 patients with chronic hepatitis C were divided into two groups: cirrhosis and non-cirrhosis. Statistical analyzes were carried out on several factors that led to the development of cirrhosis due to HCV infection. Results: The level of AST in cirrhosis group was higher than that in non-cirrhosis group, ALT level, HCVRNA level and sex composition. There was no difference in genotype 1b patients, patients infected with HCV for a long time and patients transfused with HCV more easily Cirrhosis. CONCLUSIONS: HCV infected patients develop cirrhosis with a significant impact on the time of infection, the pathways of infection, the level of AST, the genotypes of the virus and other factors, and have no significant correlation with the levels of ALT, viral load and sex.