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利用组织芯片技术检测P2 1WAF1/CIP1、PCNA与Ki - 6 7在肝细胞癌组织中的表达与分布 ,初步探讨P2 11WAF1/CIP1、PCNA与Ki- 6 7在肝细胞癌发生机制以及预后评估方面的作用。采用免疫组化技术结合临床病理资料检测了 6 1例肝癌和 5 0例癌旁组织的P2 1WAF1/CIP1、PCNA、Ki- 6 7的表达情况。PCNA和Ki- 6 7表达与肝癌的分化程度相关 ,PCNA与肝癌的侵袭转移潜力有关 (P <0 0 5 ) ,P2 1WAF1/CIP1在实验中未见有明显差异 ,但在表达程度与肝癌组织的分化程度之间亦存在着一定的相关关系。应用组织芯片高效检测临床组织样本具有快速、方便、经济、准确的优点。P2 1WAF1/CIP1、PCNA与Ki- 6 7的异常表达可能与肝癌的发生发展密切相关
The expression and distribution of P2 1 WAF1 / CIP1, PCNA and Ki - 67 in hepatocellular carcinoma were detected by tissue microarray technique. The mechanisms of P2 11 WAF1 / CIP1, PCNA and Ki- 6 7 in hepatocellular carcinoma and their prognosis were discussed Role. Immunohistochemistry and clinicopathological data were used to detect the expression of P2 1 WAF1 / CIP1, PCNA and Ki- 6 in 61 cases of HCC and 50 cases of adjacent tissues. The expression of PCNA and Ki- 67 was correlated with the degree of differentiation of HCC, PCNA was correlated with the invasion and metastasis potential of HCC (P <0.05), while P2WAF1 / CIP1 showed no significant difference in the experiment. However, There is also a certain correlation between the degree of differentiation. The application of tissue microarray to efficiently detect clinical tissue samples has the advantages of quickness, convenience, economy and accuracy. The abnormal expression of P2 1WAF1 / CIP1, PCNA and Ki- 6 7 may be closely related to the occurrence and development of hepatocellular carcinoma