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小鼠、家兔和家犬于感染血吸虫尾蚴后第7天,口服青蒿-双胺,1周1次,连续4周,减虫率达95％～100％. 青蒿-双胺对小鼠的急性LD(?)为1,200±150mg/kg,健康犬对药物的耐受性良好,副反应轻微,各项实验室指标试验结果表明对重要脏器无明显变化. 临床双盲法试验377例,结果提示预防保护率达94.4％,而副作用常见为轻度胃肠道和神经系统反应,各项实验室检查未发现有临床意义的变化.提示青蒿-双胺是一种有效的预防日本血吸虫病的药物。
In mice, rabbits and domestic dogs on the 7th day after infection with Schistosome cercariae, oral administration of artesunate - diamine, once a week for 4 weeks, worm reduction rate of 95% to 100%. Artesunate - bisamine small The acute LD (?) Of rats was 1,200 ± 150mg / kg, healthy dogs were well tolerated by drugs with minor side effects, and the laboratory test results showed that there was no significant change in vital organs. Cases, the results suggest that the prevention and protection rate of 94.4%, while the side effects are common mild gastrointestinal and nervous system reactions, the laboratory tests found no clinically significant changes. That artesunate - bisamine is an effective preventive Japanese schistosomiasis drug.