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作者在此前瞻性、随机交叉临床试验中对三种常用睾酮处方进行了药代动力学与药效学的比较。测定15例性腺机能低下男子的血浆游离和总睾酮及其比率(未结合睾酮比例)、性激素结合球蛋白(SHBG)、雌二醇、黄体生成素(LH)及卵泡刺激素(FSH)。具后人均按随机序列进行了三个疗程的治疗,其间有2个清除期的间隔。处理方法:1.隔2周肌肉注射混合睾酮酯250mg(30mg睾酮丙酸盐,60mg 睾酮苯丙酸盐,60mg 睾酮异已酸盐和100mg 睾酮癸酸盐)×4周,清除期4周。2.口服睾酮十一烷酸盐120mg 2次/日×4周,清除期1周。3.皮下(下腹部)埋植溶化结晶睾酮小丸(6×100mg)。清除期即血浆睾酮和促性腺激素月水平回升至病人本身的基础值。
The authors compared the pharmacokinetics and pharmacodynamics of three commonly used testosterone prescriptions in this prospective, randomized, cross-over clinical trial. Plasma free and total testosterone and their ratios (unconjugated testosterone ratio), sex hormone binding globulin (SHBG), estradiol, luteinizing hormone (LH) and follicle stimulating hormone (FSH) were measured in 15 hypogonadal men. After the per capita by random sequence for three courses of treatment, there are two clearance interval. Treatment: 1. Every 2 weeks intramuscular injection of a mixture of testosterone ester 250mg (30mg testosterone propionate, 60mg testosterone phenylpropionate, testosterone 60mg testosterone and 100mg testosterone caprate) × 4 weeks, the removal period of 4 weeks. 2. Oral testosterone undecanoate 120mg 2 times / day × 4 weeks, removal period of 1 week. 3. Subcutaneous (lower abdomen) embedded in molten testosterone pellets (6 × 100mg). The clearance phase of plasma testosterone and gonadotropin levels rose to the patient’s basic level.