论文部分内容阅读
多形核中性粒细胞(PMN)作为机体重要的固有免疫效应细胞,是机体抵抗病原微生物感染的第一道防线。早期的研究认为PMN仅作为吞噬细胞在结核分枝杆菌(Mtb)感染的早期参与抗结核病的固有免疫应答,但近年来的研究显示PMN还参与了结核病适应性免疫的诱导和调节,对结核病免疫的发展有重要的影响。目前,人们对其在结核病免疫过程中发挥的确切功能、对结核发生发展的影响及相关机制还未完全明了,然而近年来越来越多的研究正逐步加深我们对PMN在结核病免疫中的作用的认识。现就近年来有关PMN在结核病免疫中的研究进展进行综述。
Polymorphonuclear neutrophils (PMNs), as the important innate immune effector cells, are the first line of defense against pathogenic microorganisms in the body. Earlier studies suggested that PMN is only involved in phagocytic cells as an innate immune response against tuberculosis in the early stages of M. tuberculosis infection, but recent studies have shown that PMN is also involved in the induction and regulation of tuberculosis-adaptive immunity and immunity to tuberculosis The development has a significant impact. At present, its exact function in the process of TB immunity and its impact on tuberculosis development and its related mechanisms are not completely understood. However, more and more researches are gradually deepening our role in PMN immunization in tuberculosis in recent years Understanding. In recent years, the progress of research on PMN in tuberculosis immunization is reviewed.