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本文通过双抗体夹心Ｅｌｉｓａ法检测了４１例原发性肾病综合征患儿和３０名健康同龄儿的血清可溶性白细胞介素２受体α（ｓＩＬ－２Ｒα）的水平。并研究了ｓＩＬ－２Ｒα与血清白蛋白，白蛋白／球蛋白、和尿素氮的关系。结果表明复发组ｓｌＬ－２Ｒα明显高于初发组和正常对照，三者间有极显著差异（Ｐ＜０．００５），ｓＩＬ－２Ｒα与血清白蛋白、白蛋白／球蛋白呈负相关（Ｐ＜０．０１），与尿素氮呈正相关（Ｐ＜０．０１）提示血清ｓＩＬ－２Ｒα可能在原发性肾病综合征发病机理中起重要作用，并与病情密切相关。。
In this study, the serum soluble interleukin 2 receptor alpha (sIL-2Rα) levels in 41 children with primary nephrotic syndrome and 30 healthy children were detected by Elisa method. The relationship between sIL-2Rα and serum albumin, albumin / globulin, and urea nitrogen was also studied. The results showed that the level of sIL-2Rα was significantly negatively correlated with serum albumin and albumin / globulin (P <0.005) in the relapsed group <0.01), which was positively correlated with urea nitrogen (P <0.01), suggesting that serum sIL-2Rα may play an important role in the pathogenesis of primary nephrotic syndrome and is closely related to the disease. .