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目的进一步探讨血脂、脂蛋白、载脂蛋白在糖尿病性视网膜病变（ＤＲ）发生发展中的作用。方法对８９名糖尿病患者的血脂、脂蛋白、载脂蛋白资料进行了总结。结果显示血浆总胆固醇（ＣＨＯ）、高密度脂蛋白（ＨＤＬ）、载脂蛋白ＡＰＯＢ、ＡＰＯＣ２在有糖尿病性视网膜病变组较无糖尿病性视网膜病变组明显增高（Ｐ＜０．０５）。增殖期与非增殖期之间无明显差异。ＨＤＬ、ＬＰＡ、ＣＨＯ、ＡＰＯＡ１、ＡＰＯＡ２、ＡＰＯＣ３与当天的空腹血糖成正相关（Ｐ＜０．０５）。经过Ｌｏｇｉｓｔｉｃ回归分析显示糖尿病患者的血糖和血胆固醇水平影响糖尿病性视网膜病变的发生发展。结论患者的血糖和血胆固醇影响其糖尿病视网膜病变的发生发展，因此糖尿病患者不仅应控制血糖还应控制血脂水平
Objective To explore the role of serum lipids, lipoproteins and apolipoproteins in the development of diabetic retinopathy. Methods The data of blood lipids, lipoproteins and apolipoproteins in 89 diabetic patients were summarized. The results showed that plasma total cholesterol (CHO), high density lipoprotein (HDL), apolipoproteins APOB, APOC2 in diabetic retinopathy group were significantly higher than those without diabetic retinopathy (P <0.05). There was no significant difference between proliferative and non-proliferative phases. HDL, LPA, CHO, APOA1, APOA2 and APOC3 had positive correlation with fasting blood glucose (P <0.05). Logistic regression analysis showed that the blood glucose and blood cholesterol level of diabetic patients affected the occurrence and development of diabetic retinopathy. Conclusion Patients with blood glucose and blood cholesterol affect the development of diabetic retinopathy, so patients with diabetes should not only control blood sugar but also control the level of blood lipids