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前列腺癌的病死率在西欧、北美占第二位,在我国也有增多之趋势。现就其现状简介如下。一、基础研究前列腺癌的病因在染色体和分子基因水平上有不少新发现。在前列腺癌组织中已观察到第7或第10染色体长臂上有结构重组,第10染色体长臂缺失或改变。第8、10、16染色体上的异变可能是前列腺癌的始动发病因素。研究还发现,在前列腺癌及其转移灶中有P_(53)等位基因突变。这种突变不仅剥夺了P_(53)的抑癌作用,而且导致了胞核表现型的变化。还有人指出P_(53)的改变在前列腺癌的始动发
The mortality rate of prostate cancer in Western Europe, North America accounted for second, in our country there is also an increasing trend. Now the status quo is as follows. First, the basic research The cause of prostate cancer in the chromosomal and molecular gene levels have many new findings. It has been observed in prostate cancer tissues that there is structural recombination on the long arm of chromosome 7 or 10 and that the long arm of chromosome 10 has been deleted or altered. Mutations on chromosomes 8, 10 and 16 may be the initiating factor for prostate cancer. The study also found that there is P53 allele mutation in prostate cancer and its metastasis. This mutation not only deprived of P_ (53) tumor suppressor effect, but also led to changes in nuclear phenotype. It was also pointed out that P_ (53) changes in prostate cancer initiation