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选取参加中国2型糖尿病肿瘤发生风险流行病学调查的普查人群9390人(男性2400例,女性6990例),并将其按颈动脉内膜厚度(CIMT)分为CIMT正常组(CIMT﹤1.0mm)和CIMT增厚组(CIMT≥1.0mm)。对与CIMT相关等危险因素进行进一步评估。结果 CIMT增厚组患者的年龄、腰围、腰臀比、BMI、收缩压、舒张压、FPG、2hPG、HbA1c、UACR、HDL-C、LDL-C、TC、TG、UA均明显高于CIMT正常组,高密度脂蛋白明显低于正常对照组。年龄、收缩压、HbAlc、腰臀比、低密度脂蛋白与CIMT呈正相关(P<0.05),性别、舒张压、高密度脂蛋白与CIMT呈负相关(P<0.05),FPG、2hPG、BMI、TC、TG、UACR、UA与CIMT、无相关性(P>0.05)。结论年龄、性别、收缩压、HbAlc、腰臀比、低密度脂蛋白、舒张压、高密度脂蛋白均是颈动脉内膜增厚的独立危险因素。
A total of 9,390 people (2,400 males and 6,990 females) were enrolled in the Census Epidemiological Survey of Type 2 Diabetes in China. CIMTs were divided into CIMT normal group (CIMT <1.0mm ) And CIMT thickening group (CIMT≥1.0mm). Risk factors such as CIMT are further assessed. Results The age, waist circumference, waist-hip ratio, BMI, systolic blood pressure, diastolic blood pressure, FPG, 2hPG, HbA1c, UACR, HDL-C, LDL-C, TC, TG and UA in patients with CIMT thickening were significantly higher than those with normal CIMT Group, high-density lipoprotein was significantly lower than the normal control group. Age, systolic blood pressure, HbAlc, waist-hip ratio, and low density lipoprotein were positively correlated with CIMT (P <0.05). Sex, diastolic blood pressure and high density lipoprotein were negatively correlated with CIMT, FPG, 2hPG, , TC, TG, UACR, UA and CIMT, no correlation (P> 0.05). Conclusion Age, sex, systolic blood pressure, HbAlc, waist-hip ratio, low density lipoprotein, diastolic blood pressure and high density lipoprotein are all independent risk factors of carotid intima-media thickness.