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模拟DNA化学结构,设计并合成了双亲共聚物聚(2,2’-(1,10-二氮杂-[18]冠-6-1,10-二基)二乙基5-((腺嘌呤-9-基)甲基)间苯二甲酸酯)(PDCAI),利用扫描电镜(SEM)观测了其在水溶液中的自组织形态,采用红外光谱法(FT-IR)研究了其与底物胸腺嘧啶(thymine)的氢键识别,并以变温红外进一步证实和考察了氢键的形成及断裂.同时,尝试了利用K+对PDCAI的自组织形态和氢键识别进行了调控,结果表明:在水溶液中PDCAI自发聚集成条带状聚集体,利用K+调控可使其聚集形态转变为棒状、纳米管状或螺旋棒状;在水溶液中底物thymine的C_2=O与PDCAI进行了氢键识别,而通过K+调控,氢键识别基变为thymine的C_4=O,说明PDCAI聚集形态的转变导致thymine在与其识别过程中进行识别构象的重组织.PDCAI的研制对研究揭示聚合物自发形成螺旋的分子特征、制备螺旋型聚合物、研制新型药物载体及功能调控具有参考意义.
The DNA chemical structure was simulated and the amphiphilic poly (2,2 ’- (1,10-diaza- [18] crown-6-1,10-diyl) diethyl 5 - ( Purine-9-yl) methyl) isophthalate) (PDCAI) was synthesized and its self-organization in aqueous solution was observed by scanning electron microscopy (SEM) Hydrogen bond recognition of substrate thymine, and the formation and cleavage of hydrogen bonds were further confirmed and investigated by temperature-dependent infrared (IR) .At the same time, attempts were made to regulate the PDCAI self-organization and hydrogen bond recognition by K + PDCAI aggregates spontaneously into strip-like aggregates in aqueous solution, and the aggregation of PDCAI can be transformed into rod-shaped, nanotube-like or spiral rod shape by K + regulation. Hydrogen bond recognition between C_2 = O of thymine and PDCAI in aqueous solution, However, through the K + regulation, the hydrogen bond recognition group changed to C_4 = O of thymine, indicating that the transformation of PDCAI aggregated morphology led to the recognition of thymine in the process of its recognition. The research of PDCAI revealed that the spontaneous formation of helical molecules Characteristics, preparation of spiral polymer, development of new drug carriers and functional regulation have reference value.