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目的研究左乙拉西坦对伴中央-颞区棘波的良性癫痫(BECTS)患儿临床症状及脑电图、智力的影响。方法回顾性分析2015年1月至2016年1月在本院进行治疗的BECTS患儿,经左乙拉西坦治疗的25例作为观察组,采取卡马西平治疗的25例作为对照组。评价两组患儿的临床疗效和不良反应情况,比较两组患儿治疗前和治疗3个月后脑电图情况、智力水平。结果观察组总的有效率和对照组比较无显著性差异[92.00%(23/25)比88.00%(22/25)(P>0.05)。观察组的脑电图改善总有效率显著高于对照组[92.00%(23/25)比60.00%(15/25)](P<0.05)。观察组患儿的语言智商、操作智商、获得总智商评分显著高于对照组[(97.54±3.02)分、(110.21±3.54)分、(107.34±3.42)分比(95.49±2.76)分、(108.22±3.32)分、(104.32±3.12)分](P<0.05)。结论 BECTS患儿采取左乙拉西坦和卡马西平进行治疗,均能有效改善患儿的临床症状,但相对于卡马西平,左乙拉西坦更能有效改善患儿的脑电图和智力水平,不良反应率相对较低,安全性高。
Objective To investigate the effects of levetiracetam on the clinical symptoms, electroencephalogram (EEG) and intelligence of benign epilepsy (BECTS) children with central-temporal spikes. Methods A total of 25 children with BECTS treated with levetiracetam in our hospital from January 2015 to January 2016 were selected as the observation group and 25 patients treated with carbamazepine as the control group. Evaluation of clinical efficacy and adverse reactions in both groups of children, compared with two groups of children before treatment and after 3 months of treatment EEG situation, intelligence level. Results The total effective rate in the observation group was no significant difference compared with the control group [92.00% (23/25) vs 88.00% (22/25) (P> 0.05). The total effective rate of EEG in observation group was significantly higher than that in control group [92.00% (23/25) vs 60.00% (15/25)] (P <0.05). The scores of language IQ and IQ in the observation group were significantly higher than those in the control group [(97.54 ± 3.02), (110.21 ± 3.54), (107.34 ± 3.42), (95.49 ± 2.76, 108.22 ± 3.32) points, (104.32 ± 3.12) points (P <0.05). Conclusions The treatment of levetiracetam and carbamazepine in children with BECTS can effectively improve the clinical symptoms of children, but compared with carbamazepine, levetiracetam can effectively improve the EEG and Intelligence level, the rate of adverse reactions is relatively low, high safety.