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目的多项研究提示细胞间黏附分子-1(ICAM-1)+469A/G基因多态性与癌症有关,但结果还不确定。本研究拟系统评价ICAM-1+469A/G基因多态性与癌症风险之间的关系。方法在Pubmed、Embase、中国知网、万方、维普等数据库中检索评估ICAM-1+469A/G基因多态性与癌症风险之间关系的研究论文,提取数据并使用STATA12.0进行统计分析。结果共15个研究合计11 491例研究对象纳入本次Meta分析。结果表明,ICAM-1+469A/G基因多态性与癌症风险无关(GG+AG vs.AAOR=1.00,95%CI:0.94-1.06,P=0.927;GGvs.AG+AA OR=1.01,95%CI:0.92-1.12,P=0.78)。基于癌症类型的亚组分析显示ICAM-1+469A/G基因多态性与与乳腺癌、结直肠癌、黑色素瘤没有关联。基于人种的亚组分析表示ICAM-1+469A/G基因多态性可能会增加亚洲人群的肿瘤风险(GG vs.AG+AAOR=1.19,95%CI:1.01-1.40,P=0.033),而与高加索人种癌症风险无关。结论目前的Meta分析的证据不支持ICAM-1+469A/G多态性作为癌症的危险因素。还需要进一步的研究来验证这些发现。
PURPOSE Several studies have suggested that ICAM-1 + 469A / G polymorphism is associated with cancer, but the results are uncertain. This study was to systematically evaluate the relationship between ICAM-1 + 469A / G polymorphism and cancer risk. Methods We searched PubMed, Embase, CNKI, Wanfang, VIP and other databases to evaluate the relationship between ICAM-1 + 469A / G polymorphism and cancer risk. Data were extracted and analyzed by STATA12.0 . Results A total of 11 studies included 11 491 subjects who were included in this meta-analysis. The results showed that the polymorphism of ICAM-1 + 469A / G was not associated with the risk of cancer (GG + AG vs.AAOR = 1.00,95% CI: 0.94-1.06, P = 0.927; GGvs.AG + AA OR = 1.01,95 % CI: 0.92-1.12, P = 0.78). Subgroup analysis based on the type of cancer showed no association between ICAM-1 + 469A / G gene polymorphism and breast cancer, colorectal cancer, melanoma. A population-based subgroup analysis indicated that ICAM-1 + 469A / G polymorphism may increase cancer risk in Asian populations (GG vs. AG + AAOR = 1.19, 95% CI: 1.01-1.40, P = 0.033) But not with Caucasians cancer risk. Conclusions The current meta-analysis of evidence does not support the ICAM-1 + 469A / G polymorphism as a risk factor for cancer. Further research is needed to validate these findings.