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眼部给药剂型常采用滴眼剂和眼膏剂。由于滴眼剂具有价格低,病人易于接受,容易配制等优点,滴眼剂应用十分广泛。随着生物药剂学的发展和眼部用药后药物动力学的深入研究,发现滴眼剂在眼部药物利用度很低(1～10％),而对于需要进行长期治疗的眼部疾病,即使反复使用也很难达到预期目的,同时,还可能引起全身毒性反应。近年来,眼部给药新剂型的研究已成为一个引人注目的课题。
Eye formulations often use eye drops and eye ointment. Due to the low price of eye drops, the patient easy to accept, easy preparation, etc., eye drops are widely used. With the development of biopharmaceuticals and in-depth study of pharmacokinetics after ophthalmic administration, eye drops have been found to have low availability of ophthalmic drugs (1 to 10%), and for eye diseases requiring long-term treatment, even though Repeated use is also very difficult to achieve the desired purpose, at the same time, may also cause systemic toxicity. In recent years, the study of new dosage forms for ocular administration has become a compelling topic.