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目的:探讨单独及联合检测HE4、CA125及CEA对卵巢上皮癌的诊断意义。方法:电化学发光法检测79例卵巢上皮癌、83例卵巢良性肿瘤患者及82例健康查体女性血清中HE4、CA125及CEA水平。分析HE4、CA125及CEA水平与卵巢上皮癌临床病理特征的关系。受试者工作曲线(ROC曲线)分析单独与联合检测卵巢上皮癌的灵敏度和特异度。结果:卵巢上皮癌组的血清HE4、CA125、CEA水平明显高于卵巢良性肿瘤组及健康查体组,差异均有统计学意义(P均<0.05),后两组比较则无明显差异(P>0.05)。卵巢上皮癌组患者中,临床病理期别越晚,血清HE4水平越高(P<0.05),肿瘤分化程度越低,CA125水平越高(P<0.05)。联合检测HEA、CA125和CEA ROC曲线下面积大于单独检测(P<0.05)。结论:联合检测HE4、CA125、CEA比单独检测对卵巢上皮癌有更好的诊断价值。
Objective: To investigate the diagnostic value of HE4, CA125 and CEA on epithelial ovarian cancer separately and jointly. Methods: The levels of HE4, CA125 and CEA in serum of 79 patients with epithelial ovarian cancer, 83 patients with benign ovarian tumor and 82 healthy controls were detected by electrochemiluminescence. The relationship between HE4, CA125 and CEA levels and clinicopathological features of ovarian epithelial carcinoma was analyzed. The receiver operating curve (ROC curve) was used to analyze the sensitivity and specificity of ovarian epithelial carcinoma alone and in combination. Results: The levels of serum HE4, CA125 and CEA in ovarian epithelial carcinoma were significantly higher than those in benign ovarian tumor and healthy volunteers (P <0.05), but there was no significant difference between the two groups (P > 0.05). In the patients with epithelial ovarian cancer, the later stage of clinical pathology, the higher the level of serum HE4 (P <0.05), the lower the degree of tumor differentiation, the higher the level of CA125 (P <0.05). The area under the ROC curve of combined detection of HEA, CA125 and CEA was greater than that of single detection (P <0.05). Conclusion: The combined detection of HE4, CA125 and CEA have better diagnostic value than epithelial ovarian cancer alone.