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目的分析艾滋病抗病毒治疗终止的原因及其可能的影响因素。方法收集福建省2004年1月到2013年12月的艾滋病抗病毒治疗患者资料,共计2 639例,分析基线情况对终止治疗的影响。两组间计数资料采用χ2检验,等级资料比较采用Mann-Whitney U秩和检验和Pearson积差相关分析,多因素分析采用logistic回归分析。结果 2 639例艾滋病患者中,301例在开始抗病毒治疗后因各种原因终止治疗。艾滋病患者终止治疗的主要原因为死亡(188例,占62.46%),其次是失访(57例,占18.94%),最后是停药(56例,占18.60%)。年龄较大、开始治疗前有相关疾病及症状体征、抗体确证到启动治疗的时间间隔短和基线CD4+T细胞水平低增加患者终止治疗概率。结论加强依从性教育,在符合治疗标准后尽早开始治疗可以减少艾滋病抗病毒治疗患者终止治疗。
Objective To analyze the reason of termination of HIV antiviral therapy and its possible influencing factors. Methods A total of 2639 HIV / AIDS patients were collected from January 2004 to December 2013 in Fujian Province. The impact of baseline conditions on termination therapy was analyzed. Chi-square test was used to compare the count data between two groups. The rank data were analyzed by Mann-Whitney U rank sum test and Pearson’s product difference analysis. Multivariate analysis was performed by logistic regression analysis. RESULTS Of the 2 639 AIDS patients, 301 discontinued treatment for various reasons after initiating antiviral therapy. The main cause of termination of treatment for AIDS patients was death (188 cases, 62.46%), followed by loss of follow-up (57 cases, 18.94%) and finally discontinuation (56 cases, 18.60%). Older, before the start of treatment related diseases and signs and symptoms, antibody confirmation to start the treatment of short intervals and baseline CD4 + T cell low increase in patients with the probability of termination of treatment. Conclusions Intensifying compliance education, and starting treatment as early as possible after meeting the standard of care can reduce the termination of ART in patients with ARV.