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目的分析2014—2015年如东县岔河镇中心卫生院住院患者抗菌药物使用强度(AUD),以提高合理用药水平。方法统计2014—2015年如东县岔河镇中心卫生院住院患者抗菌药物使用情况,并对抗菌药物AUD与影响因素进行分析。结果 2014、2015年抗菌药物销售金额在药品销售总金额中的占比分别为34.4%、35.6%,抗菌药物使用率分别为56.8%、50.7%,AUD分别为51.10〔DDD·(100人)-1·d-1〕、40.20〔DDD·(100人)-1·d-1〕,较2014年,2015年抗菌药物使用率、AUD下降。2014、2015年AUD排名均在前5位的抗菌药品种类为第2代头孢菌素、青霉素类、氟喹诺酮类、其他β-内酰胺类、第3代头孢菌素。2014、2015年住院患者AUD排序均在前10位的抗菌药物有氨曲南、头孢西丁、头孢克肟、头孢米诺、头孢丙烯、头孢替安、头孢呋辛、美洛西林,其中大部分为注射剂,头孢克肟、头孢丙烯、克拉霉素为口服制剂。结论本院住院患者抗菌药物使用情况尚存在不足之处,需进一步加强管理,以促进临床合理用药。
Objective To analyze the intensity of antimicrobial use (AUD) of inpatients in Chahe Central Hospital from 2014 to 2015 in order to improve the rational use of drugs. Methods The usage of antimicrobial agents in hospitalized patients in Chahe Central Health Center from 2014 to 2015 was analyzed. And the antimicrobial drugs AUD and influencing factors were analyzed. Results The sales volume of antimicrobial drugs in 2014 and 2015 respectively accounted for 34.4% and 35.6% of the total drug sales respectively. The antimicrobial usage rates were 56.8% and 50.7% respectively, and the AUDs were 51.10 [DDD · (100 persons) - 1 · d-1], 40.20 [DDD · (100 persons) -1 · d-1], and the AUD decreased compared with that of 2014 and 2015. The top 5 antimicrobial agents in 2014 and 2015 were the second generation cephalosporins, penicillins, fluoroquinolones, other β-lactams and the third generation cephalosporins. Among the top 10 antimicrobial agents in the ORs of inpatients in 2014 and 2015, there were aztreonam, cefoxitin, cefixime, cefminoxime, cefprozil, cefotiam, cefuroxime, and mezlocillin, among which large Part of the injection, cefixime, cefprozil, clarithromycin oral preparation. Conclusion There are still some shortcomings in the use of antimicrobial agents in inpatients in our hospital. Management should be further strengthened to promote rational drug use in clinical practice.