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患者,男,42岁,因患风湿性关节炎口服阿斯匹林8周后出现恶心、呕吐、食欲减退等胃刺激症状,于1997年11月8日给予吗丁啉(西安扬森制药有限公司1997年2月生产,批号9702211)10mg,每日3次,4d后渐出现咳嗽,胸闷,呼吸困难,随入院治疗。查体:T36.2C,P84次/min;R43次/min,BP14/9kPa,呼吸急促,双肺可闻及弥漫性哮鸣音,以呼气时为甚,心率84次/min,律齐,心音有力,各瓣膜听诊区未闻及杂音,腹软,肝脾未触及,神经系统检查未见异常。实验室检查:RBC4.6×10~(12)/L,Hb130g/L,WBC8.4×10~9/L,N0.64,L0.30,E0.6;心电图及胸腹X线检查未见异常。考虑为阿斯匹林所致哮喘,停用阿斯匹林和吗丁啉,立即吸氧,静脉推注地塞米松10mg,氨茶碱0.25g,10%葡萄糖酸钙10ml,4h后症状消失,以后未再服用阿斯匹林。出院后1周,病人仍有
The patient, male, 42 years old, suffered from nausea, vomiting and loss of appetite, and other gastric irritation symptoms after oral administration of aspirin for 10 weeks due to rheumatoid arthritis, was given domperidone on Nov. 8, 1997 Company in February 1997 production, batch number 9702211) 10mg, 3 times a day, 4d gradually cough, chest tightness, difficulty breathing, with hospitalization. Examination: T36.2C, P84 times / min; R43 times / min, BP14 / 9kPa, shortness of breath, lungs can be heard and diffuse wheeze, exhaled even more, heart rate 84 beats / min, , Strong heart sounds, the valve auscultation area did not smell and noise, abdominal soft, liver and spleen not touched, nervous system examination showed no abnormalities. Laboratory tests: RBC4.6 × 10 ~ (12) /L, HB130g / L, WBC8.4 × 10 ~ 9/L, N0.64, L0.30, E0.6; ECG and chest X-ray examination did not See abnormalities. Consider aspirin-induced asthma, aspirin and morphine discontinued, immediately oxygen, intravenous dexamethasone 10mg, aminophylline 0.25g, 10% calcium gluconate 10ml, 4h after the symptoms disappear , No further aspirin after taking. One week after discharge, the patient still has