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目的：比较茶色素与吉非贝齐治疗高脂、高尿酸血症的疗效及其安全性。方法：高脂血症病人１２５例，分为茶色素组８０例（男性５４例，女性２６例，年龄 ６５ ａ± ｓ ６ ａ），给茶色素 １２５ ｍｇ， ｔｉｄ × ６０ｄ；吉非贝齐组４５例（男性２９例，女性１６例，年龄６４ ａ± ５ａ），给吉非贝齐 ３００ ｍｇ， ｔｉｄ × ６０ ｄ。结果：２组降 ＴＣ总有效率分别为 ８２％， ６３％（ Ｐ＞ ０． ０５），降ＴＧ总有效率分别为８４％，8ｌ％（Ｐ＞０．０５），升ＬDＬ－Ｃ的总有效率分别为 ７４％， ６５％（ Ｐ＞ ０． ０５），高脂血症伴高尿酸血症４１例，用茶色素治疗后，血尿酸呈非常显著性下降（Ｐ＜０．０１）。茶色素组未发现不良反应。吉非贝齐组有１９例（４２％）ＡＬＴ-过性升高。结论：茶色素与吉非贝齐调脂作用相似，茶色素降高血尿酸作用确切，且安全。
Objective: To compare the efficacy and safety of tea pigment and gemfibrozil in the treatment of hyperlipidemia and hyperuricemia. Methods: A total of 125 patients with hyperlipidemia were divided into eight groups (54 males and 26 females, age 65 a ± s 6 a), tea pigment 125 mg, tid × 60 days, gefitinib group Forty-five (29 males and 16 females, age 64 a ± 5 years) received gemfibrozil 300 mg, tid × 60 d. Results: The total effective rates of lowering TC in the two groups were 82% and 63%, respectively (P 0. 05). The total effective rate of lowering TG was 84% and 81% respectively (P 0.05) The effective rates were 74% and 65% (P> 0.05) respectively. There were 41 cases of hyperlipidemia and hyperuricemia. After treatment with tea pigment, serum uric acid showed a very significant decrease (P <0.01). Tea pigment group found no adverse reactions. In the gemfibrozil group, 19 (42%) had elevated ALT levels. Conclusion: Tea pigment and gemfibrozil similar to the role of lipid-lowering, uric acid lowering effect of tea pigment accurate and safe.