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实验结果表明,灵芪安神口服液能明显缩短戊巴比妥钠阈剂量小鼠的睡眠发生时间及提高小鼠对热致痛反应的痛阈值;能明显拮抗环磷酰胺对小鼠脾脏重量、脾脏指数及外周血白细胞数的抑制作用;能明显提高环磷酰胺抑制小鼠脾脏空斑形成细胞的数目及血清溶菌酶含量。最大耐受量实验表明,小鼠口服灵芪安神口服液的最大耐受量为临床用量的120倍,腹腔注射的LD_(50)为57.54±6.76g/kg(b=8.06)。
The experimental results show that Lingqi Anshen Oral Liquid can significantly shorten the sleep time of mice with a threshold dose of pentobarbital sodium and improve the pain threshold of mice in response to heat-induced pain; it can significantly antagonize the weight of spleen in mice with cyclophosphamide. Spleen index and peripheral blood leukocyte number inhibition; can significantly increase the number of plaque forming cells and serum lysozyme content in mice spleen by cyclophosphamide. The maximum tolerated dose experiment showed that the maximum tolerated dose of oral Lingbi Anshen Oral Liquid was 120 times of the clinical dosage, and the LD_(50) of intraperitoneal injection was 57.54±6.76 g/kg (b=8.06). ).