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目的:探讨T细胞酶联免疫斑点法(TSPOT-TB)在早期诊断尘肺合并结核中的价值。方法:应用TSP0T-TB、痰查抗酸杆菌、PPD及结核抗体对128例单纯尘肺患者,12例痰菌阳性的尘肺合并结核患者,105例结核患者,96例其他肺部疾病患者进行检测,对检查结果进行比较。结果:尘肺组(128例)中TSPOT-TB、痰查抗酸杆菌、PPD、结核抗体阳性检出率分别为19.53%、0%、67.19%、25%,尘肺合并结核组(12例)中TSPOT-TB、痰查抗酸杆菌、PPD、结核抗体阳性检出率分别为100%、100%、100%、66.67%,结核组(105例)中TSPOT-TB、痰查抗酸杆菌、PPD、结核抗体阳性检出率分别为100%、26.67%、91.43%、64.76%,其他组(96例)中TSPOT-TB、痰查抗酸杆菌、PPD、结核抗体阳性检出率分别为3.12%、0%、70.83%、19.79%。结论:TSP0T-TB在结核病高发区对尘肺合并结核的早期诊断相比痰查抗酸杆菌、PPD、结核抗体的传统方法更有价值。
Objective: To investigate the value of T cell immunospot assay (TSPOT-TB) in the early diagnosis of pneumoconiosis complicated with tuberculosis. Methods: TSP0T-TB, sputum acid-fast bacilli, PPD and tuberculosis antibody were used to detect 128 patients with simple pneumoconiosis, 12 patients with sputum-positive pneumoconiosis and tuberculosis, 105 patients with tuberculosis and 96 patients with other pulmonary diseases. Check the results for comparison. Results: The positive rates of TSPOT-TB, sputum acid-fast bacilli, PPD and tuberculosis antibodies in pneumoconiosis group were 19.53%, 0%, 67.19% and 25% respectively, and in pneumoconiosis and tuberculosis group (12 cases) The positive rates of TSPOT-TB, sputum acid-fast bacilli, PPD and tuberculosis antibody were 100%, 100%, 100% and 66.67% respectively in tuberculosis group (105 cases) , The positive rates of TB antibody were 100%, 26.67%, 91.43%, 64.76% respectively. The positive rates of TSPOT-TB, acid-fast bacilli sputum, PPD and tuberculosis antibody in other groups were 3.12% , 0%, 70.83%, 19.79%. CONCLUSIONS: TSP0T-TB is more valuable for the early diagnosis of pneumoconiosis complicated with tuberculosis than in traditional methods of sputum acid-fast bacilli, PPD, and tuberculosis antibodies in high incidence of tuberculosis.