早产儿高胆红素血症对神经系统的远期影响及早期干预的研究

• 作 者: 曹勇 宫龙基 赵荣安 于海青 刘玉欣
• 机 构: 青岛市残疾儿童医疗康复中心,青岛市残疾儿童医疗康复中心,青岛市残疾儿童医疗康复中心,青岛市残疾儿童医疗康复中心,青岛市残疾儿童医疗康复中心 266011,266011,266011,266011,26
• 出 处: 中国计划生育学杂志
• 发表日期: 1998年05期
• 关键词: 远期影响 胆红素浓度 精神发育迟滞 早期干预 血清总胆红素 干预组 新生儿期 胆红素水平 出生胎龄 视觉障碍

对1985～1996年收治的早产儿伴黄疸308例按不同血清总胆红素浓度分组,进行早期光疗和行为干预,并分别在2岁、5岁时随访发现,未干预组神经系统异常47.7％,干预组34.2％,两组有显著差异。异常顺位为精神发育迟滞、听力异常、运动落后、语言障碍和视觉障碍。总胆红素在137μmol/L以上时远期神经系统异常显著增加。提示早产儿高胆红素血症对神经系统的远期影响显著,早期干预能明显降低神经系统异常的发生率。

308 cases of preterm infants with jaundice admitted from 1985 to 1996 were divided into different groups according to the total serum bilirubin concentrations. Early phototherapy and behavioral intervention were performed. At the age of 2 and 5 years, respectively, we found that the nervous system in the non-intervention group was 47.7% , Intervention group 34.2%, there are significant differences between the two groups. Abnormal sequence of mental retardation, abnormal hearing, exercise out of touch, language barriers and visual disorders. Total bilirubin at 137μmol / L or more when the long-term abnormalities in the nervous system increased significantly. Tip hyperbilirubinemia preterm children have significant long-term effects on the nervous system, early intervention can significantly reduce the incidence of nervous system abnormalities.