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环磷酰胺(CP)是已知的致畸剂,其对大鼠致畸有效剂量范围和最佳给药时间的研究已有许多报道,但对小鼠致畸作用剂量及给药时间的研究不多,且实验结果也不一致。有人报告,给孕小鼠5～10mg/kg CP(腹腔注射)未见畸形发生。在孕后第8～12天分别给予2009/kg CP,出现多种足畸形,而40mg/kg CP就足以引起100％胚胎死亡。也有人报告,给妊娠11～14天的DM/MK小鼠注射50和100mg/kg CP可产生腭裂、并趾和卷
Cyclophosphamide (CP), a known teratogen, has been reported in many studies on the teratogenic effective dose range and the optimal administration time in rats. However, studies on the teratogenicity dose and administration time in mice Not much, and the experimental results are inconsistent. It was reported to pregnant mice 5 ~ 10mg / kg CP (intraperitoneal injection) did not deformity. 2009 / kg CP was given on the 8th to 12th postnatal day, with various foot deformities, whereas 40mg / kg CP was sufficient to cause 100% embryo death. It has also been reported that injecting 50 and 100 mg / kg of CP to DM / MK mice 11 to 14 days of gestation produces cleft palate and the toe and roll