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目的：通过肝内胆管三维结构重建，预测肝外胆道闭锁的预后。方法：对２例肝外胆道闭锁和１例对照的肝组织进行二维病理观察。系列组织切片在计算机辅助下，重建肝内胆管的三维构形。结果：二维病理学研究显示，胆道闭锁、肝内胆管增生、炎症和肝组织纤维化明显。胆道闭锁２例的肝内胆管三维构形是相似的，小叶间胆管弯曲扩张并形成微囊肿；增生的胆管主要来自赫令管，多数赫令管管腔开放并且互相连结形成网络状，少数赫令管形成膨大盲端。结论：①肝外胆管闭锁的三维构形变化是检测预后的依据之一；②小叶间胆管的微囊肿和赫令管膨大盲端，指示肝外胆道闭锁不适合肝肠吻合术而需要肝移植治疗
OBJECTIVE: To predict the prognosis of extrahepatic biliary atresia by reconstructing the three-dimensional structure of intrahepatic bile duct. Methods: Two-dimensional pathological observation was performed on 2 cases of extrahepatic biliary atresia and 1 case of control liver tissue. Series of tissue sections in the computer-assisted reconstruction of intrahepatic bile duct three-dimensional configuration. Results: Two-dimensional pathological studies showed that biliary atresia, intrahepatic bile duct hyperplasia, inflammation and liver fibrosis were obvious. Biliary atresia in 2 cases of intrahepatic bile duct is similar to the three-dimensional configuration, interlobular bile duct dilatation and the formation of micro-cysts; hyperplastic bile duct mainly from Helling, most of Hearing tube lumen open and connected to form a network, a few hehe Let the tube form an enlarged blind end. Conclusion: (1) The three-dimensional configuration change of extrahepatic biliary atresia is one of the bases of prognosis; (2) The microcirculation of the interlobular bile duct and the enlarged blind end of Healing tube indicate that the extrahepatic biliary atresia is not suitable for hepatico-intestinal anastomosis and liver transplantation is needed