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目的研究心肌局部肾素、血管紧张素Ⅱ（ＡｎｇⅡ）及去甲肾上腺素（ＮＥ）在心肌顿抑发病中的作用，以及呋喃丙吡啶（Ｆ３）对心肌顿抑是否具有保护作用。方法采用冠状动脉结扎法建立兔心肌顿抑模型，用放射免疫法测定肾素、ＡｎｇⅡ及ＮＥ的变化，缺血前用呋喃丙吡啶静脉给药。结果心肌缺血后局部肾素活性有升高趋势，再灌注后心肌局部肾素活性显著高于正常对照组。心肌局部ＡｎｇⅡ含量明显高于正常对照组。心肌ＮＥ含量明显升高。缺血前静脉推注呋喃丙吡啶可以降低心肌顿抑时心肌局部ＡｎｇⅡ及ＮＥ的产生。结论心肌局部肾素，ＡｎｇⅡ及ＮＥ在心肌顿抑的发病中具有重要意义，缺血前静脉应用呋喃丙吡啶防治可能是有益的。
Objective To investigate the role of renin, angiotensin Ⅱ (Ang Ⅱ) and norepinephrine (NE) in the pathogenesis of myocardial stunning and the protective effect of furanopyridine (F3) on myocardial stunning. Methods The rabbit model of myocardial stunning was established by coronary artery ligation. The changes of renin, Ang Ⅱ and NE were measured by radioimmunoassay. Furanopyridine was administered intravenously before ischemia. Results Local renin activity increased after myocardial ischemia, and renin activity in myocardium after reperfusion was significantly higher than that in normal control group. Myocardial Ang Ang content was significantly higher than the normal control group. Myocardial NE content was significantly increased. Prefusion of propofol with isoflurane can reduce the production of AngⅡ and NE in myocardium during myocardial stunning. Conclusion Myocardial renin, angiotensin Ⅱ (AngⅡ) and NE are important in the pathogenesis of myocardial stunning. Prevention and treatment of propofol may be beneficial in pre-ischemic venous.