Effects of Scutellaria baicalensis on neurogenesis in the hippocampal dentate gyrus and on spatial m

• 作 者: Sun-Hwa Lee Byung-soo Ahn Bong-soo Lim Seong-Kyu Kim Sam-Ki Kim Dae-II Lee Sung-Rae Cho Deok-Gon Kim Jae-Bok Han Byung-II Min
• 机 构: Department of East-West Medicine,Graduate School,Kyunghee University,Seoul,Korea“,”Department & Rese
• 出 处: 中国神经再生研究（英文版）
• 发表日期: 2011年27期
• 关键词: Scutellaria baicalensis neurogenesis dentate gyrus hippocampus bromodeoxyuridine

We investigated the effects of ethanol extracted Scutellaria baicalensis (EESB) on spatial memory function and neurogenesis in the hippocampal dentate gyrus. Adult Sprague-Dawley rats were orally administered 50, 100, or 200 mg/kg of EESB for 6 successive days. The radial-arm maze test showed that 200 mg/kg of EESB improved the spatial memory of adult rats. Confocal microscopy results showed that 100 mg/kg of EESB increased the number of bromodeoxyuridine (BrdU)- and neuron-specific nuclear protein-positive cells in the granular cell layer, and that 100 and 200 mg/kg of EESB increased the number of BrdU-/neuron-specific nuclear protein-positive cells in the sub-granular zone. 200 mg/kg of EESB increased the number of BrdU-/glial fibrillary acid protein-positive cells in the subgranular zone. These findings indicate that EESB can effectively promote neurogenesis in the hippocampal dentate gyrus and improve spatial memory function.