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虽然三价口服脊髓灰质炎疫苗(OPV)的普遍使用使得全球范围麻痹型脊髓灰质炎的发病率显著下降,但在热带和亚热带地区3剂以上OPV的免疫原性仍很低,尤其是I和Ⅲ型病毒。本文评估了影响OPV免疫原性的因素。 作者在巴西1395名新生儿和冈比亚1087名<6周龄的婴儿中进行了一项随机试验,试验采用4种配方的OPV:(1)I、Ⅱ和Ⅲ型脊髓灰质炎病毒含量分别为10、1和3×10~5半数组织培养感染量(TCID_50),即10:1:3(标准
Although the widespread use of the trivalent oral polio vaccine (OPV) has led to a significant decrease in the incidence of paralytic poliomyelitis worldwide, the immunogenicity of more than 3 doses of OPV in the tropics and subtropics remains low, notably I and Type III virus. This article assesses the factors that influence the immunogenicity of OPV. The authors conducted a randomized trial of 1395 infants in Brazil and 1087 infants <6 weeks of age in the Gambia using four formulations of OPV: (1) the poliovirus types I, II and III were 10 , 1 and 3 × 10 ~ 5 half number of tissue culture infection (TCID_50), that is 10: 1: 3 (standard