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目的了解血清游离脂肪酸(FFA)在高血压伴代谢综合征(MS)发病机制中的作用。方法选取高血压伴MS、单纯高血压、健康人群各50例。检测所有对象的FFA、体重指数(BMI)、腰臀比(WHR)和外周胰岛素敏感度(SI)等指标。结果①MS高血压病组的血清FFA高于单纯高血压组及健康对照组(P<0.05)。②血清FFA与SI呈负相关(r=-0.785,P<0.05),与BMI、WHR、收缩压(SBP)呈正相关(r=0.801、0.856、0.872,P<0.05)。结论高血压伴MS患者的高血清FFA与胰岛素抵抗并存,并有可能是引起高血压伴MS患者其他病理生理改变的主要机制。
Objective To understand the role of serum free fatty acid (FFA) in the pathogenesis of hypertension with metabolic syndrome (MS). Methods Select hypertension with MS, simple hypertension, healthy population of 50 cases. All subjects were tested for indicators of FFA, body mass index (BMI), waist-hip ratio (WHR) and peripheral insulin sensitivity (SI). Results ① The serum FFA of MS patients with hypertension was higher than that of patients with hypertension and healthy controls (P <0.05). ② Serum FFA was negatively correlated with SI (r = -0.785, P <0.05), and positively correlated with BMI, WHR and SBP (r = 0.801,0.856,0.872, P <0.05). Conclusions Both high serum FFA and insulin resistance co-exist in patients with hypertension and MS and may be the main mechanism of other pathophysiological changes in patients with hypertension and MS.