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目的提高对免疫低下患者镰刀菌感染的认识,探讨治疗方案。方法报道1例急性髓性白血病化疗后合并镰刀菌感染患者的临床表现、治疗经过和转归。结果患者女,54岁,化疗后出现发热,全身红色丘疹,组织培养见大量菌丝,涂片见大量孢子,经两性霉素B及伏立康唑抗真菌治疗,病情一度稳定,但最终突发脑出血,抢救无效死亡。结论镰刀菌感染是急性髓性白血病化疗后少见的致死性并发症,对异常皮肤损害应尽快进行组织涂片及培养,早期明确诊断,及时给予抗真菌治疗。
Objective To improve the understanding of Fusarium infection in immunocompromised patients and to explore the treatment plan. Methods One case of acute myeloid leukemia after chemotherapy combined with Fusarium infection in patients with clinical manifestations, treatment and prognosis. Results The female patient, 54 years old, had fever after chemotherapy, systemic red papules, a large amount of mycelium in tissue culture, numerous spores in smear, antifungal therapy with amphotericin B and voriconazole, the condition was stable at one time, but the final sudden cerebral hemorrhage , Rescue invalid death. Conclusion Fusarium infection is a rare fatal complication after chemotherapy for acute myeloid leukemia. Tissue smear and culture should be carried out as soon as possible for abnormal skin lesions. Early diagnosis and antifungal therapy should be given.