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他汀类药物是目前临床上广泛使用的调脂药,近年来他汀类药物的非调脂作用日益引起人们的重视。动物实验发现,他汀类药物对缺血再灌注心肌有保护作用。大规模的临床试验也证实他汀类药物能有效减少冠脉事件的发生,并可以减少短期内冠脉事件再发的危险性,且长期应用受益更大。目前研究认为他汀类药物对缺血再灌注心肌的保护作用主要是通过改善内皮功能和抗炎作用实现的,也可通过动员内皮祖细胞、抗血栓、提高心肌能量及抗氧化损伤等机制有效的减轻缺血再灌注损伤。
Statins are currently widely used in clinical lipid-lowering drugs, non-lipid-lowering effects of statins in recent years has drawn increasing attention. Animal experiments found that statins have a protective effect on myocardial ischemia-reperfusion. Large-scale clinical trials also confirmed that statins can effectively reduce the incidence of coronary events, and can reduce the risk of recurrence of coronary events in the short term, and long-term use to benefit even more. The current study suggests that statins can protect myocardium against ischemia-reperfusion injury mainly by improving endothelial function and anti-inflammatory effects, and can also be effective by mobilizing endothelial progenitor cells, anti-thrombosis, improving myocardial energy and anti-oxidative injury Reduce ischemia-reperfusion injury.