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目的:评价液基薄层细胞学技术(TCT)联合高危型人乳头状瘤病毒(HPV)在子宫颈病变的诊断价值。方法:对发现宫颈异常的患者同时TCT及高危HPV检测,对一项或两项异常者行病理组织学检查,并以病理结果为金标准。对106例病理结果宫颈上皮内瘤变(CINI、II、III)的患者,比较两种方法的检出敏感度。结果:TCT检测阳性者80例,敏感度为75.5%,HPV DNA检测阳性90例,敏感度84.9%,经统计学分析,TCT及HPV两种方法的检测结果没有统计学差异(P>0.05)。两种方法都是病理级别越高检出率越高。结论:该两种方法在宫颈早期病变的筛查中不能相互替代;两种方法联合应用可使阳性检出率提高。
Objective: To evaluate the diagnostic value of liquid-based TLCT combined with high-risk human papilloma virus (HPV) in cervical lesions. Methods: Simultaneous TCT and high-risk HPV were detected in patients with cervical abnormalities. Pathological examination was performed on one or two abnormal patients. The pathological results were taken as the gold standard. In 106 patients with pathological findings of cervical intraepithelial neoplasia (CINI, II, III), the detection sensitivity of the two methods were compared. Results: The TCT test was positive in 80 cases, the sensitivity was 75.5%, HPV DNA test was positive in 90 cases, the sensitivity was 84.9%. There was no statistical difference between the two methods (P> 0.05) . Both methods are the higher the pathological level the higher the detection rate. Conclusion: The two methods can not replace each other in the screening of early cervical lesions; the combination of the two methods can increase the positive detection rate.