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Abbott79175为第二代5脂氧合酶抑制剂,其化学名称为(R)(+)N[3[5(4氟代苯氧基)2呋喃基]1甲基2丙炔基]N羟基尿素。本文报道研究其晶体的多晶现象。将药物从未控制水分的乙酸乙酯庚烷系统中以及从乙醇水系统中结晶,均生成晶型。差示扫描量热法测定、热重分析以及含水量分析(KarlFi
Abbott 79175 is a second generation 5 lipoxygenase inhibitor with the chemical name of (R) (+) N [3 [5 (4fluorophenoxy) furyl] methylpropynyl] N hydroxy Urea. This article reports the polycrystalline phenomenon of its crystals. The drug is formed from an ethyl acetate-heptane system that has never been controlled for water and from an ethanolic water system. Differential Scanning Calorimetry, Thermogravimetric Analysis and Water Content Analysis (KarlFi