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目的:探讨激素联合丙种球蛋白治疗多发性硬化的疗效。方法:选取于2012年07月至2013年07月在我院进行治疗的42例多发性硬化患者,按照随机分组方式将其分为治疗组和对照组。对照组21例患者采用激素治疗,而治疗组21例患者在对照组治疗基础上,给予患者丙种球蛋白进行治疗。临床观察对比两组患者治疗前后的临床及免疫学指标。结果:治疗组和对照组在治疗前,两组患者的神经功能障碍量表评分结果没有显著性差别,但是治疗组治疗前后的神经功能障碍量表评分结果有明显差异,同时治疗组治疗后的神经功能障碍量表评分结果和对照组相比较,也存在显著性差异,两组结果对比有显著性差异(P<0.05),因此对比结果具有统计学意义。结论:激素联合丙种球蛋白治疗多发性硬化的临床效果非常好,可以通过非特异性的免疫调节机制调节患者机体的免疫功能,有效改善患者的临床症状,值得在临床上推广应用。
Objective: To investigate the effect of hormones combined with gamma globulin in the treatment of multiple sclerosis. Methods: Forty-two patients with multiple sclerosis who were treated in our hospital from July 2012 to July 2013 were randomly divided into treatment group and control group. Twenty-one patients in the control group were treated with hormone therapy, and 21 patients in the treatment group were treated with gamma globulin on the basis of the control group. Clinical observation of two groups of patients before and after treatment of clinical and immunological indicators. Results: Before the treatment, there was no significant difference between the two groups in the score of neurological dysfunction scale, but there was a significant difference in scores of neurological dysfunction before and after treatment in the treatment group and the control group There was also a significant difference between the scores of neurological dysfunction scale and the control group, the results of the two groups were significantly different (P <0.05), so the results of the comparison were statistically significant. Conclusion: The clinical effect of hormones combined with gamma globulin in the treatment of multiple sclerosis is very good. It can regulate the immune function of patients through nonspecific immunomodulatory mechanism and effectively improve the clinical symptoms of patients. It is worth popularizing and applying in clinic.