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本工作研究了花生油及油酸对由消炎痛所致的大鼠胃粘膜损伤的保护作用。用花生油1.0ml,油酸0.25、0.5和1.0ml 灌胃均能明显地减轻由消炎痛引起的胃粘膜损伤,其中油酸的作用还呈现明显的量-效关系。而30%甘油、油酸乙酯、5%葡萄糖或0.1%乙酸各1.0ml灌胃则无效。将油酸注入空肠,其作用与灌胃相似。阿托品、酚妥拉明和心得安不能阻断油酸的上述保护作用。这些结果表明,花生油及油酸具有明显的保护胃粘膜的作用。油酸这种作用主要不是通过提供能量,也不是通过副交感神经和交感神经传递,而可能是通过它作用于小肠刺激多种胃肠激素释放而产生的。
This work studied the protective effects of peanut oil and oleic acid on gastric mucosal injury induced by indomethacin in rats. With peanut oil 1.0ml, oleic acid 0.25, 0.5 and 1.0ml gavage can significantly reduce the gastric mucosal damage caused by indomethacin, of which the role of oleic acid also showed a significant dose-effect relationship. While 30% glycerol, ethyl oleate, 5% glucose or 0.1% acetic acid each 1.0ml gavage is invalid. The oleic acid into the jejunum, its role and gavage similar. Atropine, phentolamine and propranolol can not block the above protective effect of oleic acid. These results show that peanut oil and oleic acid have a significant protective effect on gastric mucosa. This effect of oleic acid is mainly caused not by the supply of energy, nor by the parasympathetic and sympathetic nerve transmission, but by its action on the small intestine to stimulate the release of various gastrointestinal hormones.