【摘 要】
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Nerve-cancer interactions modulate pancreatic cancer growth through direct effects on cancer cells and the microenviron-ment.New evidence now shows that nerves
【机 构】
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Department of Medicine,Division of Digestive and Liver Diseases and Herbert Irving Comprehensive Can
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Nerve-cancer interactions modulate pancreatic cancer growth through direct effects on cancer cells and the microenviron-ment.New evidence now shows that nerves supply metabolic support to tumors by transporting amino acids to the nutrient-poor microenvironment.rn Many studies have now shown that the nervous system plays an important role in the development and progression of numerous types of cancer,particularly pancreatic ductal adeno-carcinoma(PDAC).1-6 Similar in many ways to the effects of neoplasia on blood vessel growth and angiogenesis,pancreatic and other cancers modulate the neural microenvironment,promoting the outgrowth of axonal fibers towards the tumor and leading over time to a greater density and size of nerves within tumors.7 While much of the early focus was on the findings of perineural invasion,with the invasion of nerve trunks by cancer,thus providing an additional pathway for spread,more recent reports have pointed to direct modulation of tumor growth by neural signaling.1-4 Thus,there is a clear crosstalk between pancreatic tumors and the surrounding nerves,resulting in a remodeling of the neural microenvironment in a fashion more conducive to tumor growth.
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