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目的探讨多囊卵巢综合征(PCOS)与体重指数对体外受精-胚胎移植(IVF-ET)临床结局的影响。方法在IVF-ET中根据体重指数BMI≥25和<25分为A组(肥胖)和B组,A组中合并PCOS的为A1组(100人),非PCOS(350人)为A2组,B组中合并PCOS为B1组(116人),非PCOS为B2组(600人)。所有患者的年龄≤35岁,PCOS与非PCOS一般情况匹配。比较各组的着床率、临床妊娠率、早期流产率、活产率。结果 A1、A2、B1、B2 4组的临床妊娠率相似(44.0%v49.0%v44.8%v49.0%),但是AI组早期流产率(27.3%v12.3%v7.7%v10.0%)和活产率(16.0%v35.4%v41.4%v35.2%),与其它三组的相比均显著性降低(16.0%v35.4%v41.4%v35.2%),P<0.05,而其它三组(A2组、B1组和B2组)的流产率和活产率相似,差别无统计学意义。结论年轻患者中,PCOS合并肥胖影响妊娠结局,而瘦型PCOS、单纯性肥胖对临床结局影响不大。
Objective To investigate the effects of PCOS and body mass index on the clinical outcome of in vitro fertilization-embryo transfer (IVF-ET). Methods According to body mass index BMI≥25 and <25, IVF-ET was divided into group A (group A) and group B (group B) In group B, PCOS was combined with group B1 (116) and group B (600) with non-PCOS. All patients ≤35 years of age, PCOS and non-PCOS general match. The implantation rate, clinical pregnancy rate, early miscarriage rate and live birth rate of each group were compared. Results The clinical pregnancy rates in groups A1, A2, B1 and B2 4 were similar (44.0% v49.0% v44.8% v49.0%), but the rate of early miscarriage in AI group was 27.3% v12.3% v7.7% v10 .0%) and the live birth rate (16.0% v35.4% v41.4% v35.2%) were significantly decreased compared to the other three groups (16.0% v35.4% v41.4% v35.2 %), P <0.05, while the other three groups (A2, B1 and B2) abortion rate and live birth rate were similar, the difference was not statistically significant. Conclusions In young patients, PCOS combined with obesity affects pregnancy outcome, whereas lean PCOS and simple obesity have little effect on clinical outcome.