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目的探讨肠内营养不同治疗时限对老年肺心病心衰患者血清炎性因子及心功能的影响。方法以90例老年肺心病心衰患者为研究对象,将患者随机分为三组,三组在常规治疗心衰同时,A组给予自由饮食,B组给予肠内营养治疗1月,C组给予肠内营养治疗6月。各组治疗前后均检测各营养指标,用放免发测TNF-α、IL-6,用心脏超声检测左室射血分数LVEF。结果肠内营养组患者在治疗后各营养指标均有改善,炎性因子水平均有降低,心功能均有所改善,治疗前后比较有统计学意义(P<0.05),尤其在C组中改善更为明显(P<0.01)。自由饮食组中,治疗后各营养指标无改善,血清炎性因子水平及心功能有所改善,但治疗前后比较无统计学意义(P>0.05)。结论老年肺心病心衰患者,在常规治疗心衰同时重视肠内营养治疗,可以改善患者营养状况从而改善免疫功能,调节炎性因子水平,进一步改善患者心功能,并且治疗时限越长心功能及炎性因子水平改善越明显。
Objective To investigate the effect of different enteral nutrition treatment on serum inflammatory factors and cardiac function in elderly patients with cor pulmonale heart failure. Methods A total of 90 elderly patients with heart failure of pulmonary heart disease were enrolled in this study. The patients were randomly divided into three groups. The three groups were given routine treatment of heart failure at the same time. Group A received free diet. Group B received enteral nutrition for 1 month, Enteral nutrition treatment in June. Before and after treatment, each index of nutrition was detected, TNF-α and IL-6 were measured by radioimmunoassay, and left ventricular ejection fraction LVEF was measured by echocardiography. Results In the enteral nutrition group, all the nutritional indexes improved, the levels of inflammatory cytokines decreased, the cardiac function improved, and there was statistical significance before and after treatment (P <0.05), especially in group C More obvious (P <0.01). In the free diet group, there was no improvement in the nutritional indexes after treatment, serum inflammatory factors and cardiac function were improved, but there was no significant difference before and after treatment (P> 0.05). Conclusions Elderly patients with heart failure of pulmonary heart disease often treat enteral nutrition in the treatment of heart failure, which can improve the nutritional status of patients to improve the immune function, regulate the level of inflammatory cytokines, further improve the cardiac function, and the longer the treatment time, Inflammatory factor levels improve the more obvious.