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目的介绍近年来多肽修饰脂质体靶向药物递送系统的研究进展。方法查阅和归纳总结近几年相关文献。结果阐述了精氨酸-甘氨酸-天冬氨酸(RGD)多肽、丙氨酸-脯氨酸-精氨酸-脯氨酸-甘氨酸(APRPG)多肽、细胞穿透肽(CPP)、血管活性肠肽(VIP)等修饰脂质体的研究进展。多肽修饰的包载药物的脂质体可以增加药物在体内的选择性,减少药物毒副作用,提高药物治疗指数。结论多肽分子是机体内一类重要的生物活性物质,将其作为导向物以配体-受体特异性结合的方式应用于靶向药物递送系统,具有良好的研究价值和应用前景。
Objective To introduce the research progress of peptide-modified liposome-targeted drug delivery system in recent years. Methods Review and summarize the relevant literature in recent years. Results The effects of arginine-glycine-aspartate (RGD) polypeptide, alanine-proline-arginine-proline-glycine (APRPG) polypeptide, cell penetrating peptide (CPP) Research Progress on Modified Liposomes such as VIP. Peptide modified drug-loaded liposomes can increase the selectivity of the drug in the body, reduce drug side effects and improve the drug treatment index. CONCLUSION: Peptide is an important bioactive substance in the body. It has been widely used as targeted drug delivery system in the way of ligand-receptor specific binding. It has good research value and application prospect.