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目的探讨贝那普利联合吲达帕胺治疗高血压合并心力衰竭患者的临床疗效。方法选取2013年5月至2015年6月中国人民解放军第210医院收治的85例高血压合并心力衰竭患者作为研究对象,按随机数字表法将其分为对照组(40例)和观察组(45例)。对照组患者在常规治疗基础上口服贝那普利,观察组患者在对照组基础上联合吲达帕胺进行治疗,比较两组患者治疗前后收缩压(SBP)、舒张压(DBP)、左心室收缩末期内径(LVDS)、左心室舒张末期内径(LVDD)、左心室射血分数(LVEF)、6 min步行距离(6MWT)、临床疗效及不良反应发生情况。结果观察组患者治疗的总有效率明显高于对照组,差异有统计学意义(P<0.05);治疗后,观察组患者的SBP、DBP均明显低于对照组,差异均有统计学意义(均P<0.05);治疗后,观察组患者的LVDD、LVDS均明显低于对照组,LVEF、6WMT均明显高于对照组,差异均有统计学意义(均P<0.05)。两组患者治疗前后未出现肝肾功能异常等不良反应。结论贝那普利联合吲达帕胺治疗高血压合并心力衰竭患者临床疗效明显,可明显改善患者心脏功能,提高血压控制效果,无严重不良反应,安全有效。
Objective To investigate the clinical efficacy of benazepril combined with indapamide in the treatment of patients with hypertension and heart failure. Methods From May 2013 to June 2015, 85 patients with hypertension complicated with heart failure admitted to Chinese People’s Liberation Army 210th Hospital were divided into control group (40 cases) and observation group 45 cases). The patients in the control group were treated with benazepril orally on the basis of routine treatment. The patients in the observation group were treated with indapamide on the basis of the control group. The SBP, DBP, LVDS, LVDD, LVEF, 6MWT, clinical efficacy and incidence of adverse reactions. Results The total effective rate of observation group was significantly higher than that of control group (P <0.05). After treatment, SBP and DBP in observation group were significantly lower than those in control group (P <0.05) (All P <0.05). After treatment, the LVDD and LVDS in the observation group were significantly lower than those in the control group, LVEF and 6WMT were significantly higher than those in the control group (all P <0.05). Two groups of patients before and after treatment did not appear adverse liver and kidney dysfunction and other adverse reactions. Conclusion The combination of benazepril and indapamide is effective and safe in patients with hypertension and heart failure. It can significantly improve the cardiac function, improve the blood pressure control effect, without serious adverse reactions, and is safe and effective.