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用20mg 黄体酮肌注对症治疗各种病因所致的腹部绞痛病人64例。治疗后1.5h 内,完全缓解52例,部分缓解6例,无效6例(9.38%),总有效率90.63%。腹痛开始缓解平均时间45.51±17.48 min。期间除轻度利尿外无明显副反应。不缓解组的急诊手术比为5/6,与有效组比较有高度显著性差异(P<0.01)。认为黄体酮的解痉止痛机理主要与松驰内脏平滑肌有关,因此在治疗腹部绞痛,权衡采用内科保守还是急诊手术时,可将黄体酮肌注作为一项试验性治疗手段。
With 20mg progesterone intramuscular symptomatic treatment of various causes of abdominal cramps in 64 patients. Within 1.5h after treatment, complete remission in 52 cases, partial remission in 6 cases, 6 cases (9.38%), the total effective rate was 90.63%. Abdominal pain began to ease the average time of 45.51 ± 17.48 min. There was no obvious side reaction during mild diuresis. There was a highly significant difference (P <0.01) between the emergency department and the effective group in the non-remission group (5/6). That progesterone spasm and analgesic mechanism is mainly associated with relaxation of visceral smooth muscle, so in the treatment of abdominal cramps, weighing the use of conservative or emergency surgery, progesterone intramuscular injection can be used as an experimental treatment.