论文部分内容阅读
目的：观察镇痛有效剂量的布鲁生（Ｂｒｕ）对正常小鼠及Ｃｙｃ所致免疫低下小鼠非特异免疫功能的影响．方法：测定小鼠碳粒廓清能力、免疫器官重量及外周血ＷＢＣ，小鼠ＰＭ吞饮中性红及产生ＩＬ１能力．结果：Ｂｒｕ对正常鼠碳粒廓清能力、免疫器官重量、外周血ＷＢＣ、ＰＭ吞噬功能及产生ＩＬ１能力仅有轻微促进作用（Ｐ＞００５），而对被Ｃｙｃ降低的上述非特异免疫反应，Ｂｒｕ呈剂量依赖性的增强作用（Ｐ＜００５或Ｐ＜００１），作用以１０ｍｇ·ｋｇ－１时最好．结论：Ｂｒｕ在镇痛有效剂量ｉｐ时，对小鼠非特异免疫功能有剂量依赖性及功能依赖性的调节作用．
Objective: To observe the effect of Brucella, an effective analgesic dose, on non-specific immune function in mice immunocompromised by Cyc and normal mice. Methods: Determination of carbon clearance ability of mice, immune organ weight and peripheral blood WBC, mouse PM swallowing neutral red and produce IL 1 ability. RESULTS: Bru had only slight enhancement on carbon clearance, immune organ weight, peripheral blood WBC, PM phagocytosis and ability to produce IL-1 (P> 005), while the above-mentioned non-specific Immune response, Bru dose-dependent enhancement (P <0 05 or P <0 01), the role of the best 10mg · kg-1. Conclusion: Bru in the analgesic effective dose ip, non-specific immune function of mice in a dose-dependent and function-dependent regulatory role.